Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 8
2008 8
2009 7
2010 10
2011 12
2012 15
2013 22
2014 22
2015 20
2016 23
2017 23
2018 14
2019 22
2020 25
2021 13
2022 12
2023 15
2024 11

Text availability

Article attribute

Article type

Publication date

Search Results

244 results

Results by year

Filters applied: . Clear all
Page 1
Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis.
Livingston MJ, Shu S, Fan Y, Li Z, Jiao Q, Yin XM, Venkatachalam MA, Dong Z. Livingston MJ, et al. Autophagy. 2023 Jan;19(1):256-277. doi: 10.1080/15548627.2022.2072054. Epub 2022 May 18. Autophagy. 2023. PMID: 35491858 Free PMC article.
Following acute kidney injury (AKI), renal tubular cells may stimulate fibroblasts in a paracrine fashion leading to interstitial fibrosis, but the paracrine factors and their regulation under this condition remain elusive. ...These results indicate that persistent autopha …
Following acute kidney injury (AKI), renal tubular cells may stimulate fibroblasts in a paracrine fashion leading to interstitial fib …
Autophagy activates EGR1 via MAPK/ERK to induce FGF2 in renal tubular cells for fibroblast activation and fibrosis during maladaptive kidney repair.
Livingston MJ, Zhang M, Kwon SH, Chen JK, Li H, Manicassamy S, Dong Z. Livingston MJ, et al. Autophagy. 2023 Nov 18:1-22. doi: 10.1080/15548627.2023.2281156. Online ahead of print. Autophagy. 2023. PMID: 37978868
Macroautophagy/autophagy contributes to maladaptive kidney repair by inducing pro-fibrotic factors such as FGF2 (fibroblast growth factor 2), but the underlying mechanism remains elusive. Here, we show that EGR1 (early growth response 1) was induced in injured proximal tub …
Macroautophagy/autophagy contributes to maladaptive kidney repair by inducing pro-fibrotic factors such as FGF2 (fibroblast growth fa …
Pten knockout affects drug resistance differently in melanoma and kidney cancer.
Brodaczewska K, Majewska A, Filipiak-Duliban A, Kieda C. Brodaczewska K, et al. Pharmacol Rep. 2023 Oct;75(5):1187-1199. doi: 10.1007/s43440-023-00523-y. Epub 2023 Sep 6. Pharmacol Rep. 2023. PMID: 37673853 Free PMC article.
METHODS: We aimed to show the effect of CRISPR/Cas9-mediated Pten knockout on murine melanoma (B16 F10) and kidney cancer (Renca) cells. We evaluated the effect of PTEN deregulation on tumor progression in vivo and in vitro, as well as on the effectiveness of drug treatmen …
METHODS: We aimed to show the effect of CRISPR/Cas9-mediated Pten knockout on murine melanoma (B16 F10) and kidney cancer (Renca) cel …
LYC inhibits the AKT signaling pathway to activate autophagy and ameliorate TGFB-induced renal fibrosis.
Wang Y, Ping Z, Gao H, Liu Z, Xv Q, Jiang X, Yu W. Wang Y, et al. Autophagy. 2023 Nov 30:1-20. doi: 10.1080/15548627.2023.2287930. Online ahead of print. Autophagy. 2023. PMID: 38037248
Renal fibrosis is a typical pathological change in chronic kidney disease (CKD). Epithelial-mesenchymal transition (EMT) is the predominant stage. ...The results showed that LYC could inhibit the AKT signaling pathway to activate mitophagy and reduce renal fibrosis.Abbrevi …
Renal fibrosis is a typical pathological change in chronic kidney disease (CKD). Epithelial-mesenchymal transition (EMT) is the predo …
Upregulation of Piezo2 in the mesangial, renin, and perivascular mesenchymal cells of the kidney of Dahl salt-sensitive hypertensive rats and its reversal by esaxerenone.
Ochiai K, Mochida Y, Nagase T, Fukuhara H, Yamaguchi Y, Nagase M. Ochiai K, et al. Hypertens Res. 2023 May;46(5):1234-1246. doi: 10.1038/s41440-023-01219-9. Epub 2023 Feb 21. Hypertens Res. 2023. PMID: 36810623
These cells were positive for Pdgfrb, Col1a1, and Col3a1, but negative for Acta2 (alphaSMA), indicating that they were perivascular mesenchymal cells different from myofibroblasts. ...In salt-induced hypertensive Dahl-S rats, Piezo2 upregulation was observed in the mesangi …
These cells were positive for Pdgfrb, Col1a1, and Col3a1, but negative for Acta2 (alphaSMA), indicating that they were perivascular m …
C-atrial natriuretic peptide (ANP)4-23 attenuates renal fibrosis in deoxycorticosterone-acetate-salt hypertensive mice.
Lu YY, Li SJ, Zhang Z, He S, Guo YT, Hong MN, Shao S, Wang RQ, Zhang J, Wang JG, Gao PJ, Li XD. Lu YY, et al. Exp Cell Res. 2023 Oct 1;431(1):113738. doi: 10.1016/j.yexcr.2023.113738. Epub 2023 Aug 10. Exp Cell Res. 2023. PMID: 37572787
Moreover, C-ANP(4-23) inhibited DOCA-salt treatment-induced renal EMT as evidenced by decrease of the mesenchymal marker alpha-smooth muscle actin (ACTA2) and vimentin and increase of epithelial cell marker E-cadherin. ...The key transcription factors (twist, snail, slug a …
Moreover, C-ANP(4-23) inhibited DOCA-salt treatment-induced renal EMT as evidenced by decrease of the mesenchymal marker alpha-smooth muscle …
Single cell G-protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21.
Kaur H, Yerra VG, Batchu SN, Tran DT, Kabir MDG, Liu Y, Advani SL, Sedrak P, Geldenhuys L, Tennankore KK, Poyah P, Siddiqi FS, Advani A. Kaur H, et al. Br J Pharmacol. 2023 Nov;180(22):2898-2915. doi: 10.1111/bph.16101. Epub 2023 May 31. Br J Pharmacol. 2023. PMID: 37115600
Here, we set out to establish a transcriptional profile that identifies activated kidney fibroblasts and the GPCRs that they express. EXPERIMENTAL APPROACH: RNA sequencing and single cell qRT-PCR were performed on mouse kidneys after unilateral ureteral obstruction …
Here, we set out to establish a transcriptional profile that identifies activated kidney fibroblasts and the GPCRs that they express. …
Soluble dipeptidyl peptidase-4 induces epithelial-mesenchymal transition through tumor growth factor-β receptor.
Huang CW, Lee SY, Du CX, Ku HC. Huang CW, et al. Pharmacol Rep. 2023 Aug;75(4):1005-1016. doi: 10.1007/s43440-023-00496-y. Epub 2023 May 26. Pharmacol Rep. 2023. PMID: 37233949
BACKGROUND: Kidney fibrosis is the final manifestation of chronic kidney disease, a condition mainly caused by diabetic nephropathy. ...METHODS: The influences of sDPP4 on renal epithelial cells were demonstrated by measuring the expression of EMT markers and ECM pr …
BACKGROUND: Kidney fibrosis is the final manifestation of chronic kidney disease, a condition mainly caused by diabetic nephro …
miR-34c attenuates epithelial-mesenchymal transition and kidney fibrosis with ureteral obstruction.
Morizane R, Fujii S, Monkawa T, Hiratsuka K, Yamaguchi S, Homma K, Itoh H. Morizane R, et al. Sci Rep. 2014 Apr 3;4:4578. doi: 10.1038/srep04578. Sci Rep. 2014. PMID: 24694752 Free PMC article.
On the other hand, mesenchymal-epithelial transition (EMT) and kidney fibrosis is a pathological process of chronic kidney disease (CKD), and its relationship to miRNAs is becoming recognized as a potential target for CKD therapies. ...In conclusion, our study showe …
On the other hand, mesenchymal-epithelial transition (EMT) and kidney fibrosis is a pathological process of chronic kidney dis …
Unilateral nephrectomy diminishes ischemic acute kidney injury through enhanced perfusion and reduced pro-inflammatory and pro-fibrotic responses.
Kierulf-Lassen C, Nielsen PM, Qi H, Damgaard M, Laustsen C, Pedersen M, Krag S, Birn H, Nørregaard R, Jespersen B. Kierulf-Lassen C, et al. PLoS One. 2017 Dec 21;12(12):e0190009. doi: 10.1371/journal.pone.0190009. eCollection 2017. PLoS One. 2017. PMID: 29267404 Free PMC article.
The perfusion (T1 value) was significantly enhanced in the medulla of the post-ischemic kidney following UNx. UNx decreased the expression of fibrogenic genes, i.a. Col1a1, Fn1 and Tgfb1 in the post-ischemic kidney. This was associated with a marked decrease in mark …
The perfusion (T1 value) was significantly enhanced in the medulla of the post-ischemic kidney following UNx. UNx decreased the expre …
244 results